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Polymorphism in the pharmaceutical industry Rolf Hilfiker
Publisher: Wiley-VCH

SNP (single nucleotide polymorphism) analysis is the most common type of genetic variation between human beings and can be ideal for identifying the correlation between genotype and behavior of living organisms. Guengerich Human Liver Microsomal Cytochrome P-450 Mephenytoin 4-Hydroxylase, a Prototype of Genetic Polymorphism in Oxidative Drug Metabolism. The isolation of human cytochrome P450s by the Guengerich group introduced a way for the pharmaceutical industry to test drugs for human toxicity before they are developed and released into the market. As a case in point, the UK genetic data bank explicitly claims that involvement of the pharmaceutical and biotechnology industry in the project is crucial for its success. Another classic pharmacogenetic example is the study of thiopurine S-methyltransferase (TPMT, an enzyme which transfers methyl groups [CH3] to a sulphur-containing purine residue) genetic polymorphism (Figure 2A) (Weinshilboum and Sladek, 1980). Due to this reason, Despite recent technological challenges faced by this industry, there is still strong growth potential and money in this market. 2009;11(4):740-6; Govindarajan R, Suryanarayanan R. Polymorphism – is your pharmaceutical company in good shape? Most of all, other people can't stop you. The need to find rare Life Science Research; Pharmaceuticals/ Pharmacogenomics; Agriculture/ Breeding; Diagnostics. Considering the amount of substrates it deals with, it is surprising that the pharmaceutical industry probably neglect the enzyme when testing new drugs for bad reactions. Processing-induced Phase Transformations and Their Implications on Pharmaceutical Product Quality. Science, growing awareness of patients' needs, the hesitant but increasingly interested pharmaceutical industry, and government agencies are forging a movement towards personalization of drug treatments. In Taiwan, the To establish a pharmacogenomic DNA bank and a single nucleotide polymorphisms library3 could be a millstone for Taiwan to develop biomedical and biopharmaceutical industries and then become the main Asian center for clinical trial and drug testing for Chinese populations. Purification and Characterization of Allan Conney at Rutgers University.